Supplémentation de la vitamine D 25OH chez les patients présentant un asthme allergique. ( Etude systématique )

Abstract

Title: supplementation of vitamin D 25 OH in patients with allergic asthma. Introduction: Asthma and associated allergic diseases are important public health problems around the world. Asthma remains the most common chronic disease in children and one of the main causes of morbidity. The prevalence of asthma and allergic diseases has increased rapidly in Western and industrialized countries, vitamin D deficiency occurred despite the enrichment of food in some Western countries and in areas of the world regarded as sips of sun. It has been documented that the global increase in asthma and allergic diseases can be linked to a decrease in serum hydroxyvitamin (25 (OH) d), moreover, reported that vitamin D supplementation was effective in The prevention of exacerbation of asthma, while two studies report incoherent results. Therefore, the effect of vitamin D supplementation on patients with bronchial asthma is still controversial. Methods: Our study is of a systematic type, we have included descriptive (transversal), observational (cohort and case / control) and interventional studies. (Randomized and not randomized). Published between 2011 and 2022, on the Medical Database Medical (Medical Literature Analysis and Retrieval System Online), via its free PUBMED search engine. The inclusions factors including children (4-18 years old) Adults (> 18 years old) presenting an allergic asthma and the exclusions factors: newborns and preschool children (<4 years), adults with non-allergic asthma, or other forms of allergy. Results: Searching MEDELINE, review-type studies, book chapters, we ended up with 31 articles analyzed at the end. In our study, we are trying to answer the question of the benefit of supplementation of vit D in the development of allergic asthma. For this, we analyzed in the first part, the level of vitamin D in patients with allergic asthma, children and adults, and in the second part, vitamin D supplementation in the same type of patients. For the values of vitamin D, Half of the asthmatic population presents a value of vitamin D, too low (lower than 20ng/ml). And For the second part of the study, the concentration of vitamin D-25 OH before the intervention, all the studies analyzed presented values of less than 30 ng/ml, 50% of the studies show an average vit D of less than 20 ng/ml. In contrast, two studies had an average of 35 ng/ml, and 49.8 ng/ml. Conclusion: More than three quarters of the studies, (24 vs 31 > 75%), show an average vitamin D lower than 30ng/ml, a positive association was found in the majority of the studies between vitamin D, FEV1, FEV1%, and the tiffeneau report, supplementation was beneficial in half of the studies analyzed, especially in children, with a reduction in asthma exacerbations, however, vitamin D, seems to play a role in the case of mild to intermittent asthma. further interventional studies are needed with larger doses of vitamin D on a larger scale.