Évaluation des paramètres biochimiques chez les femmes enceintes atteintes de l’hypothyroïdie

Abstract

Hypothyroidism during pregnancy is a common endocrine disorder that can affect the mother’s health and the development of the foetus. Thyroid hormones play a vital role in maintaining metabolic balance and ensuring a healthy pregnancy. Impaired thyroid function can lead to various biological disturbances that may increase the risk of obstetric and neonatal complications. The aim of this study was to assess certain biochemical parameters in pregnant women with hypothyroidism. To this end, a comparative study was conducted involving 60 pregnant women divided into two groups: a group of 30 patients with hypothyroidism and a control group comprising 30 healthy pregnant women. The parameters studied included thyroid-stimulating hormone (TSH), free thyroxine (FT4), fasting blood glucose and total cholesterol. The results showed an increase in mean TSH levels and fasting blood glucose levels in pregnant women with hypothyroidism compared with the control group. In contrast, there were no significant differences in FT4 and total cholesterol levels between the two groups. The study also highlighted a higher incidence of certain obstetric complications in hypothyroid patients. In conclusion, hypothyroidism during pregnancy is associated with biological changes that may influence the course of pregnancy. These results underscore the importance of early

screening, regular biological monitoring and appropriate management to improve the maternal- foetal prognosis.