Optimisation de l’Activité Antioxydante In Vitro de l’Huile de Pépin de Raisin

Abstract

A huge amount of waste is generated by the wine industries, especially grape pomace. Grapeseed oil (HPR) is then obtained from grape seeds from this waste. It is rich in nutrients with great nutritional and medicinal value and has high antioxidant potential including protection against oxidative damage in cells. Indeed, our study was carried out in vitro on human lymphocytes in order to evaluate the antioxidant activity of HPR and to measure some parameters of oxidative stress. The aim of this work was to model a concentration of HPR to have considerable antioxidant power. Our results showed that HPR exhibits antioxidant activity, reduced LDH and significantly decreased levels of MDA, PCARs, and enhanced the activity of antioxidant enzymes such as GSH and CAT. It seems interesting to carry out in vivo studies on rats, for example. We can easily induce the various pathologies and evaluate the activity of the PRH administered at different doses.