Preparation,optimization of polymeric formulations for oral administation of antibiotics

Abstract

Abstract: The objective in our study is the preparation of forms pharmaceuticals: disks supporting the active ingredient “cefalexin”. In the preparation of these forms, three matrix polymers were used Etylcellulose "EC", polyethylene glycol "PEG" and cellulose triacetate "CTA" which was obtained from cotton via an esterification reaction using acetic anhydride as an acetylating agent. The discs were prepared by mechanical compression with alcohol sprays. The polymers used, Cefalexin and the prepared Tablets were characterized by FTIR, XRD, the synthesis was followed by another study of the release of active ingredients in reconstituted media (pH 1.2 and 7.7) , the tablets followed by the biological study of prepared tablets with respect to the referenced bacterial strains. The results of FTIR showed that the spectrum of the Tablet 4 is only the sum of the FTIR spectra of Cefalexin, EC and CTA. The main absorption bands of CF appeared clearly in the disk spectrum comfirmed the presence of CF into the Tablet 4. This XRD technique makes it possible to characterize the nature of the polymer from a crystalline. This allows us to say that the cefalexin are dispersed in the polymer matrix; the presence of EC reduces the crystalline of the cefalexin. For all the formulation loaded with CF, the percentage of active ingredient released is greater in the medium at pH=7.7 compared to the acidic medium pH=1.2; The release was good in the medium pH 7.7 (95%) because the polymer mixture is composed of polyethylene glycol (PEG) and ethyl cellulose (EC), in an acidic environment PH 1.2 the release was around 85.93%. According to microbial activity, the inhibition diameter for the three formulations is indeed greater than 18, especially for the tablet prepared on the basis of PEG/EC. We can conclude that we have selected a good matrix from the kinetic and biological point of view.