Nouvelles stratégies de synthèse des composés polycycliques

Abstract

This thesis presents the development of eco-friendly synthetic methods for producing imidazo-heterocycles and 2-pyridones, utilizing techniques such as solvent-free synthesis, catalysis, microwave irradiation, and ultrasound. Following the successful synthesis of these compounds, their practical applications were investigated. The inhibitory effectiveness of selected imidazo- heterocyclic derivatives on mild steel corrosion was evaluated, highlighting their potential as corrosion inhibitors. Additionally, the biological activity of the synthesized imidazo[1,2-a]pyridines/pyrimidines was tested, revealing promising pharmacological properties. Molecular docking studies were performed to model the interactions of potent compounds with specific biological targets, providing insights into their therapeutic potential. This research advances the synthesis and application of heterocycles in industrial and biomedical contexts.