Hypothyroïdie : impact du traitement substitutif sur les troubles métaboliques chez les femmes de la région d’Ain Témouchent

Abstract

Hypothyroidism is a pathological situation in which there is a decrease in secretions of thyroid hormones that can influence many different metabolic pathways such as the metabolism of glucose, lipids (cholesterol, TG), nitrogen (urea and creatinine). This pathology is more common in women than men and is estimated to be prevalent with a female predominance of 4-8% and the average age of onset of the disease in women is 60 years, but there is a peak incidence at the time of menopause. This work proposes to study the impact of substitution treatment on metabolic disorders in women in the region of Ain Témouchent. A case-control study was conducted on 34 women including 17 hypothyroid women receiving levothyroxine and 17 control women. The lipid profile (triglycerides, total cholesterol, HDL- C and LDL-C) renal (urea, creatinine and uric acid) hepatic (TGO, TGP, P-AL and GGT), carbohydrate, protein and albumin were explored in hypothyroid women and the under treatment. The results show that hypothyroid women under treatment have similar serum levels compared to controls in the majority of tested parameters such as blood glucose, total cholesterol, HDL-C, LDL-C, urea, TGO, TGP, direct bilirubin, P- AL, total protein and albumin, In contrast, significant increases were observed in serum creatinine, triglyceride, GGT and uric acid levels. In conclusion, hypothyroidism causes a metabolic imbalance throughout the body, and the current substitution treatment can regulate the majority of these disturbances.